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Mutations of the UL97 protein kinase of CMV are the major cause of resistance against ganciclovir and its derivates. The resistence is determined genotypically by sequencing if the viral genes for the UL97 kinase and for the DNA polymerase. , 2008). The activity of cidofovir and foscarnet is independent of the protein kinase UL97 and appropriate for the therapy of many DNA viruses. 3 Differential diagnosis During the early disease stages, additional infectious agents, rheumatological disorders, autoimmune uveitis, or intraocular lymphomas have to be considered (Table 1).

A survey on the prevalence of orofacial herpes in France: the INSTANT study. Journal of the American Academy of Dermatology, Vol. 55, No. 2, pp. ; Baarsma, G. ; Osterhaus, A. ; Verjans, G. M. (2001). Herpes simplex virus type 1 (HSV-1)-induced retinitis following herpes simplex encephalitis: indications for brain-to-eye transmission of HSV-1. Annals of Neurology, Vol. 49, No. 1, pp. 104-106 Malkin, J. ; Hercberg, S. (2002). Seroprevalence of HSV-1 and HSV-2 infection in the general French population.

L. (2004). Immune control of herpes simplex virus during latency. Current Opinion in Immunology, Vol. 16, No. 4, pp. ; Baarsma, G. ; Schweitzer, C. ; Breebaart, A. C. (1989). Aqueous humor analysis as a diagnostic tool in toxoplasma uveitis. International Ophthalmology, Vol. 13, No. 6, pp. ; van den Horn, G. ; Baarsma, G. ; Schweitzer, C. ; Zaal, M. ; Rothova, A. (1990). Laboratory tests in uveitis. New developments in the analysis of local antibody production. Documenta Ophthalmologica, Vol. 75, No.

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