Download Antiplatelet Therapy in Cardiovascular Disease by Ron Waksman, Paul A. Gurbel, Michael A. Gaglia Jr. PDF

By Ron Waksman, Paul A. Gurbel, Michael A. Gaglia Jr.

Edited via one of many world's prime interventional cardiologists and educators, this new ebook is created with an eye fixed on giving the reader a high-quality, sensible and clinically-focused realizing of this significant category of substances, from easy technological know-how to a clear-headed dialogue of advanced subject matters resembling mixture treatments, drug-drug interactions, and platelet resistance.

This vital new book:

  • Begins with a concise yet thorough dialogue of platelet biology and pathophysiology in order that readers know the way those remedies paintings and why they could additionally produce this type of assorted variety of problems, from minor gastrointestinal dissatisfied, to in all likelihood life-threatening stipulations equivalent to neutropenia, a serious scarcity of white blood cells.
  • Thoroughly covers platelet functionality checking out, together with new, novel techniques.
  • Clarifies present best-practices in regards to the use of antiplatelet brokers in either continual and acute cardiovascular disease
  • Reviews of every kind of antiplatelet brokers – from aspirin to lately authorized medicines – together with symptoms, scientific results, and aspect effects/complications

Written via a world who's-who of specialists within the box, Antiplatelet remedy additionally contains a complete part overlaying using antiplatelet medications in PCIs, together with percutaneous valve fix, which makes this article rather necessary to Interventional Cardiologists.

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Additional resources for Antiplatelet Therapy in Cardiovascular Disease

Sample text

The effects of IV agents usually can be immediately resolved with infusion discontinuation. This might be valuable at the end of therapy or when a complication (bleeding) occurs. The benefits of these drugs have been demonstrated to be related to patient risk profile during PCI for ST-elevation myocardial infarction: the higher the patient’s risk, the higher the benefits from IV therapy [13]. IV antiplatelet drugs have also some disadvantages. Their use is confined to the acute care setting, as it requires venous access; special storage, handling, and preparation of the product; and the necessary delivery equipment, such as IV pumps.

A. (1987) Inhibition of thromboxane formation in vivo and ex vivo: implications for therapy with platelet inhibitory drugs. Blood, 69, 180–186. M. (1995) The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase. Natural Structural Biology, 2, 637–643. T. J. (2001) Structural analysis of NSAID binding by prostaglandin H2 synthase: time-dependent and time-independent inhibitors elicit identical enzyme conformations. Biochemistry, 40, 5172–5180.

Saturation is maintained during a 10 mg/min infusion (usually continued over 12–24 h), with gradual recovery of platelet function after the infusion is stopped. Short plasma half-life determined by the rapid binding to GPIIb/IIIa receptors is a characteristic feature of abciximab. This fact results in strong inhibition of platelet aggregation, while adhesion and secretion are preserved. The efficacy of abciximab may be influenced by numerous factors, such as thrombocytosis, basal platelet activation, or agonist stimulation.

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