By Yukiaki Kuroda (auth.), Yukiaki Kuroda, Delbert M. Shankel, Michael D. Waters (eds.)
From booklet information, Inc.
The papers are prepared in 8 sections, addressing: antimutagens in nutrition; antimutagens and anticarcinogens in environmental toxicology; loose radicals; antitumor initiators; antitumor promoters; facets of mammalian and human genetics; molecular elements of mutagenesis and antimutageneis; and oncogenes and antioncogenes.
Annotation copyright ebook information, Inc. Portland, Or.
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Additional resources for Antimutagenesis and Anticarcinogenesis Mechanisms II
F. Sasaki, H. Imanishi, M. Watanabe, T. Ohta, and Y. Shirasu (1988) Suppression of mitomycin C-induced micronuclei in mouse bone marrow cells by post-treatment with vanillin. Mutat. Res. 202: 93-95. , and N. Kanematsu (1978) Reduction of N-methyl-N'-nitroN-nitrosoguanidine-induced mutations by cobalt -chloride -in Escherichia coli. Proc. Japan Acad. 54(Ser. B): 234-237. , K. Morita, and T. Inoue (1978) Antimutagenic action of vegetable factor(s) on the mutagenic principle of tryptophan pyrolysate.
Sakamoto, M. Taira, S. Nishimura, Y. Shimosato, lVl. Terada, and T. Sugimura (1986) Amplifications of both c-Ki-ras with a point mutation and c-myc in primary pancreatic cancer and its metastatic tumors in lymph nodes. Jpn. J. Cancer Res. (Gann) 77:370-375. , I. Chigusa, K. N. A. Welsh, and P. Correa (1982) Geographic pathology of latent prostatic cancer. Int. J. Cancer 29:611-616. , Y. Tsunetsugu-Yokota, H. Battifora, C. J. Cline (1986) Alterations of myc, myb and ~ Ha proto-oncogenes in cancers are frequent and show clinical correlation.
Recently, a c-Ki-ras mutation at the 12th codon was demonstrated by Perucho and his colleagues in 21 of 22 cases of pancreatic cancer by the polymerase chain reaction (1). Activation of c-Ki-ras may be necessa~y, but additional multiple genetic changes may proviae-more growth advarttages for pancreatic cancers. Tab. 2. Occult and overt prostate cancer among Japanese in Japan and Hawaii. 9 a. % of cases of over 50 years old (3) b. Incidence per 100,000 head of population according to WHO data in 1982.