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By David R. Gross DVM, PhD (auth.)

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All other parameters not affected. 3mglkg, IV Decreased heart rate, cardiac output, mean aortic pressure and increases in systemic and pulmonary vascular resistance. 48 Pregnant bitches ? 6 minutes 2 Cardiovascular effects 0/ of the opiods Conditions of the Experiment Dose Cardiovascular Effects References Rate reduced, decreased contracti1e amplitude. In the contractile electrically driven atria there was electrieally .. an initial pOSItIve inotropic response whieh which preceded the negative inotropie inotropic reaction.

Responses blocked by atropine. e. daily doses prior to 15 min. infusion (n=6) Same Transient increase in aortic blood pressure with tachycardia seen during the later stages of the 15 min. 5 mg/kg, IV Decrease in heart rate and mean aortic pressure as a result of increased parasympathetic activity 105 Decapitated, isolated left atrium preparation. Electrically stimulated. M Dose related decrease in heart rate and increase in atrial tension 107 Conscious, previously instrumented 4 mg/kg, IV, every 2 hrs.

6 minutes 2 Cardiovascular effects 0/ of the opiods Conditions of the Experiment Dose Cardiovascular Effects References Rate reduced, decreased contracti1e amplitude. In the contractile electrically driven atria there was electrieally .. an initial pOSItIve inotropic response whieh which preceded the negative inotropie inotropic reaction. When the calcium ion concentration of the preparation was increased the Pentazocine induced decrease in contractility was antagonized. Pentazocine also antagonized the negative inotropic and chronotropie inotropie chronotropic effects of adenosine and acetylcholine.

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