Download Advances in DNA Repair in Cancer Therapy by Anderson T. Wang, Peter J. McHugh (auth.), Lawrence Panasci, PDF

By Anderson T. Wang, Peter J. McHugh (auth.), Lawrence Panasci, Raquel Aloyz, Moulay Alaoui-Jamali (eds.)

​A finished evaluate of the hot advancements in DNA fix study that experience strength for translational purposes. The ebook explains intimately some of the organic mechanisms wherein melanoma cells can sidestep anticancer treatment and bounds its usefulness in sufferers. in addition they evaluation the influence of such novel inhibitors of DNA fix mechanisms as methylguanine-DNA-methyltransferase. additionally tested are inhibitors of alternative DNA fix enzymes reminiscent of PARP and DNA-PK. The publication captures-for either melanoma researchers and oncologists facing hallmark "relapse" or "drug resistance" phenomena on a regular basis-the many interesting new makes use of of DNA fix inhibitors, both on my own or together with anticancer therapies.​

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Extra resources for Advances in DNA Repair in Cancer Therapy

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A key regulator of the cellular response to oxygen deprivation is the transcription factor, hypoxia-inducible factor 1 (HIF-1), whose function results in the induction of a plethora of target genes that collectively confer cellular adaptation to hypoxia [168]. Indeed, DNA-PK protects HIF-1a from degradation, indicating that DNA-PK controls the amplitude of HIF-1a accumulation under hypoxia [44]. These novel findings expand the cellular importance of DNA-PK [169] but paradoxically, compromise the therapeutic interest of its inhibition that may therefore induce side effects in uncharacterized metabolic networks.

Amongst these lesions, DSBs are considered to be major actors in cell death [1]. Similarly to ionizing radiations, most untargeted antitumor drugs cause DNA damage that induces death signals in cancer cells as well as in normal cells. DNA lesions trigger a cell response through an interconnected network called the DNA damage response (DDR) that tends to maintain cell viability and genomic stability [2, 3]. The DDR relies on a complex network of proteins that initiate and coordinate DNA repair activity by halting the cell cycle through the activation of checkpoints that block cells at the G1-S transition, the intra-S phase or the G2/M boundary [4].

Chowdhury D, Xu X, Zhong X et al (2008) A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication. Mol Cell 31(1):33–46 130. Keogh MC, Kim JA, Downey M et al (2006) A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery. Nature 439(7075):497–501 131. Douglas P, Zhong J, Ye R et al (2010) Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX. Mol Cell Biol 30(6):1368–1381 132.

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