Download Activation of Hormone and Growth Factor Receptors: Molecular by M. N. Alexis, C. E. Sekeris (auth.), Dr. Michael N. Alexis, PDF

By M. N. Alexis, C. E. Sekeris (auth.), Dr. Michael N. Alexis, Prof. Constantin E. Sekeris (eds.)

This quantity includes the papers offered within the NATO complex examine Workshop "Activation of Hormone and progress issue Receptors: Molecular Mechanisms and outcomes" held in Nafplion, Greece on September 25-30, 1988. the target of NATO ARW is to evaluate the country of-the-art in a given medical sector and to formulate suggestions for destiny learn in rising components of technological know-how via selling overseas medical contacts. within the Nafplion assembly this aim was once reached by way of a global team of audio system, senior Greek scientists and graduates excited by correct learn parts. The Workshop used to be made attainable through the beneficiant aid of the medical Council of NATO. We thank Drs. G. Sinclair and L.V. daCunha, administrators of the NATO ARW's and ASI's (Advanced examine Institutes) respectively, for his or her wholehearted help and recommendation. The foreign Union of Biochemistry provided extra shuttle can provide resulting in elevated foreign participation. in addition, the Secretariat of technology and know-how, the Ministry of tradition and Sciences and the nationwide Hellenic examine origin contributed financially and via aiding team of workers. We basically thank most of these agencies for his or her help. Our heartful thank you also are prolonged to the Mayor of the Municipality of Nafplion, Mr.

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In a recent series of experiments, we have examined the action of the R1 receptor on inositol phosphate metabolism and growth stimulation in human HeLa cells. Histamine induces a dose-dependent accumulation of inositol phosphates that parallels its mitogenic activity. Both the formation of inositol phosphates and the stimulation of cell proliferation by histamine are blocked by the HI receptor antagonist pyrilamine (Figure 2). Histamineinduced inositol phosphate formation in HeLa cells lasts for at least several hours.

R""'- r f" :1 iib ~ control 100,uM Histamine Figure 2. Histamine induced cell prolifera'tion (A) and inositol phosphate formation (B) in HeLa cells in the presence (closed bars) or absence (open bars) of 250 nM pyrilamine. Inositol phosphates were determined as in Tilly et al. (1987). In A histamine and pyrilamine were present for 48 hr prior to cell counting. It thus appears that activation of the receptor tyrosine kinase is a crucial signal that initiates the multiple postreceptor effects of EGF that lead to DNA synthesis.

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